TSH levels were obtained at set intervals for patients in the same group receiving the same dose of levothyroxine. Two groups were included: a group of patients who switched from Thyrax to another brand and a group of patients who continued taking Thyrax. Of these, 85% were women, and the average age was ~60 years. Patients taking at least 25 mcg Thyrax daily for at least one year were included. Patient information in 2 databases representing more than 25% of the Dutch population were used for this study. The current study examined the effect of the shortage of the levothyroxine brand Thyrax in the Netherlands and subsequent switch to a different brand on thyroid stimulating hormone (TSH) levels.įlinterman LE et al 2020 Impact of a forced dose-equivalent levothyroxine brand switch on plasma TSH: A cohort study. In 2016, the manufacturer of the levothyroxine brand Thyrax experienced an interruption in production that required approximately 350,000 Dutch patients to change their levothyroxine supplier. However, there is limited data on the impact of changing brands on thyroid function. Because potency of levothyroxine between manufacturers is variable, there is a possibility that changing brands may affect thyroid function tests. When levothyroxine is generic (non-branded), prescriptions may be filled with levothyroxine from different manufacturers. When levothyroxine is branded, for example Synthroid™, Levoxyl™ and Tirosint™ in the United States, Thyrax in Europe, every prescription filled is for that same brand. There are different manufacturers that make levothyroxine. Hypothyroidism can be treated with levothyroxine, the main hormone secreted by the thyroid gland. doi:10.5539/gjhs.Hypothyroidism is a condition in which the thyroid gland is underactive and does not produce enough thyroid hormone. Levothyroxine dosage requirement during pregnancy in well-controlled hypothyroid women: A longitudinal study. Kashi Z, Bahar A, Akha O, Hassanzade S, Esmaeilisaraji L, Hamzehgardeshi Z.
Hashimoto's thyroiditis and autoimmune gastritis. doi:10.5041/RMMJ.10229Ĭellini M, Santaguida MG, Virili C, et al. Thyroid hormone replacement in patients following thyroidectomy for thyroid cancer. Thyroxine and triiodothyronine content in commercially available thyroid health supplements. Comorbidities, concomitant medications, and diet as factors affecting levothyroxine therapy: Results of the CONTROL surveillance project. Treatment for primary hypothyroidism: current approaches and future possibilities. Oral liquid levothyroxine solves the problem of tablet levothyroxine malabsorption due to concomitant intake of multiple drugs. Guidelines for the treatment of hypothyroidism: Prepared by the American Thyroid Association task force on thyroid hormone replacement. The history and future of treatment of hypothyroidism. Levothyroxine dose adjustment to optimise therapy throughout a patient's lifetime.
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